Everybody is born different, some are born perfectly healthy and remain healthy for the rest of their lives, some are born with certain neuromuscular disorders, while some may develop degenerative disorders. Stem Cell Therapy (SCT) is the treatment of various disorders, non-serious to life-threatening, by using stem cells. These stem cells can be procured from a lot of different sources and used to potentially treat more than 80 disorders, including neuromuscular and degenerative disorders. Hematopoietic disorders (e.g. leukemia, thalassemia, aplastic anemia, Myelodysplastic syndromes - MDS, sickle cell anemia, storage disorders etc.) affect the bone marrow and manifest with various systemic complications. Stem cells from a donor (either from cord blood or bone marrow) are known to reconstitute the defective bone marrow and permanently overcome the disorder. Degenerative disorders arise from degeneration or wear and tear of bone, cartilage, muscle, fat or any other tissue, cell or organ. This could occur due to a variety of reasons, but it's normally the process known as aging, or 'getting old' that is the biggest cause. The disorders have a slow and insidious onset but once contracted, can be long-standing, pain-staking and lifelong. These disorders can affect any organ of the body. The common degenerative disorders are diabetes, osteoarthritis, stroke, chronic renal failure, congestive cardiac failure, myocardial infarction, Alzheimer's disease, Parkinson's disease etc.
At present, conventional treatment for many of these disorders aren't very effective, however, stem cell therapy has been showing a lot of promising results all over the world. This is possible due to the amazing and unique features of stem cells. The treatment is safe, speedy and often completed within a day or two. Yet, the results are far better than the long and ineffective conventional therapies. It is surprising to know that therapy using stem cells from various sources, including those from bone marrow and umbilical cord, has been successfully used to treat a number of life-threatening diseases with good results, since 1988. Over the past few years, with increased research and development activities, a growing number of successful stem cell treatments have emerged. It has become one of the most exciting areas of medicine, encompassing all areas of current medical science.
The stem cell samples are collected, processed and stored as per international standards that ensure the optimum yield of stem cells in adherence to the regulations. We employ a quality management system based on continuous improvement, to ensure that all aspects of its services are consistently carried out and meets international standards. At Jing-Meng, we process your precious stem cells using our proprietary technology to make sure they possess the best features required for treatment:
The stem cells banked by Jing-Meng are completely safe, non-toxic and totally devoid of side effects with an excellent probability of homing and engraftment with parent cell, tissue or organ. The lab undertakes suitable safety and toxicology studies in appropriate models based on the proposed route, dose and source of cells before embarking on trials. This will be with the approval of the animal ethics and the internal stem cell ethics committee. The Perfect HLA Match. HLA (Human Leucocyte Antigen) is present on all leucocytes and its identification and analysis are imperative for appropriate engraftment. Hence it is pertinent to offer the best matches for best outcomes. Hematopoietic cells express HLA, however mesenchymal stromal cells do not express HLA antigens, hence the research aspects and trial aspects pertaining to MSCs are relatively less cumbersome.
These are hematopoietic markers. Their adequate numbers are significant for best results based on abundant literature. For those cases where CD34+ numbers are lesser than the desired, Jing-Meng has especially embarked on a CD34+ expansion program that shall be made available soon. These are important for improving vascular proliferations during organogenesis and regenerative processes. The research program of CD34+ expansion will also be done after appropriate regulatory guidelines clearances.
Dendritic cells (DCs) are potent antigen presenting cells that form an important part of the immune system. These cells are the only cells in our body that have the capacity to induce a primary immune response. They have received scientific and clinical interest due to their key role in anti-cancer host responses.
Natural Killer (NK) cells are a component of the innate immune system which has the ability to recognize damaged, infected or transformed malignant cells. They express lytic machinery that is able to kill and target cells independently of any previous exposure to cancer antigens. Main functions of NK cells are to suppress tumor cell initiation, growth, and metastasis through mechanisms mediated by perforin and the granzyme-containing granule-mediated death receptor.
Cancer, which is still a leading cause of death in the world, is a condition where cells in a specific part of the body grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs. It sometimes begins in one part of the body before spreading to other areas, a process is known as metastasis. The causative factors could be toxic substances, radiation, genetic abnormalities etc. When the factors causing the cancer, cells are overwhelmingly powerful against the immune system, the disease becomes full blown.
Platelet Rich Plasma (PRP) is a form of cellular therapy where platelets from our own blood are used for healing. Our own blood is rich in cells that have excellent healing properties. Platelets are one kind of cells present in blood that are intimately involved in rejuvenation and regeneration. When we remove the red blood cells from blood, we get a clear liquid called plasma. Plasma contains platelets which can be concentrated to obtain platelet-rich plasma. The concentration of platelet in PRP is typically 4-5 times the baseline. PRP has been used successfully for a number of conditions ranging from tendonitis to hair loss. PRP has significant use in the treatment of orthopedic conditions such as early osteoarthritis, chondromalacia of the patella, plantar fasciitis and Achilles tendonitis. PRP contains several growth factors that aid healing. For example, they can promote angiogenesis (formation of blood vessels) and growth of chondrocytes (cells that form cartilage).
Bone Marrow Transplant is a procedure where a person’s damaged or destroyed bone marrow is replaced with healthy bone marrow stem cells. A bone marrow transplant is mainly applicable for treating certain kinds of cancer and has been in practice for more than 50 years. Bone marrow transplants are also applicable in non-cancer conditions such as auto-immune disease (such as Multiple Sclerosis) and genetic disorders (such as beta-thalassemia).
The autologous procedure is also called Bone Marrow Rescue. It is applicable when the patient’s bone marrow is not affected by the disease. Firstly, the patient’s own bone marrow is drawn out and saved. Then, high doses of chemotherapy are given, which kills cancer but also severely affects the bone marrow. The saved bone marrow is then infused back into the patient. This rescues the patient’s bone marrow while getting rid of cancer. Bone marrow rescue can also be used in auto-immune disease, where high doses of chemotherapy are given to kill immune cells that are self-reactive (which means they are attacking the patient’s own body). In the allogeneic procedure, the patient is treated with high doses of chemotherapy and then the bone marrow is replaced by healthy bone marrow obtained from a matching donor. In Vascular Disease, blood vessels are affected. They can get blocked, rupture, or degenerate. This leads to a lack of blood supply to the affected areas. Studies indicate that in some conditions, the patient’s own bone marrow stem cells can lead to the restoration of blood supply. Bone marrow cells are known to be effective in treating Peripheral Vascular Disease (a disease that leads to loss of blood supply mainly in the feet and hands). Lack of blood supply to the feet leads to a gangrenous state where there is tissue death. Until now, vascular reconstruction and angioplasty were the main options to restore blood supply. In many cases, these approaches fail and this may lead to amputation of the affected limb. Injection of bone marrow cells in such patients leads to restoration of blood supply. Evidence indicates that bone marrow cells are involved in the formation of new blood vessels. Improvement of key clinical parameters such as Ankle Brachial Index and TCPO2 was observed in patients who were scheduled for amputation. Consequently, amputation was avoided.
Dendritic cell approach to cancer therapy takes advantage of the normal role of the dendritic cell as an immune educator. These cells are naturally present in every person’s bloodstream and are a blood cell. Their usual function is to identify a foreign substance, including cancer cells, process them and bring about an immune response by bringing the foreign substances to the attention of the rest of the immune system (mostly T lymphocyte cells). The activated immune system is then able to circulate throughout the body and destroy the foreign particles. However, in cancer, the immune system often fails. The tumors affect DC maturation and differentiation and induce a generalized failure of the host to mount an effective anti-tumor response. Our protocol focuses on enhancing the dendritic cells artificially and transfusing them systemically which target the antigens (cancer cells) better and are able to mount an immune response. Cancer, which is still a leading cause of death in the world, is a condition where cells in a specific part of the body grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs. It sometimes begins in one part of the body before spreading to other areas, a process is known as metastasis. The causative factors could be toxic substances, radiation, genetic abnormalities etc. When the factors causing cancer, cells are overwhelmingly powerful against the immune system, the disease becomes full blown.
Jing-Meng has partnered with leading eye hospitals for offering cryopreservation of corneal stromal lenticules extracted for potential therapeutic use for treating conditions like hypermetropia. This would provide a safe, effective and stable alternative treatment option compared to excimer laser ablation due to fewer chances of regression; no flap-related complications, haze, postoperative ectasia, less post-operative dry eye and aberrations.
Jing-Meng routinely offers limbal stem cell culture services to leading eye hospitals for treating Limbal Stem Cell Deficiency (LSCD) caused due to Stevens-Johnson Syndrome, Chemical / thermal injuries, Aniridia & Pterygium, Herpes simplex epithelial disease, Radiation keratopathy, contact lens-induced keratopathy, Limbal tumors & Neuroparalytic keratitis and Drug toxicity. We process limbal biopsies, cultured epithelial cells in vitro and prepare the cultured epithelium with amniotic membrane for transplantation.
Amyotrophic lateral sclerosis (ALS) - also known as Lou Gehrig's disease, motor neuron disease and sometimes Charcot disease - affects nerve cells in the brain and the spinal cord. The function of these cells, which are also called motor neurons, is to carry the brain’s impulses to all the muscles in the body via the spinal cord. With the progression of ALS, motor neuron degenerate and eventually die, leaving the brain unable to initiate and control muscle movement. The patient may also become totally paralyzed. The weakness eventually hampers chewing, swallowing, speaking and breathing.
Chronic renal failure, also known as chronic kidney disorder (CKD), is a condition in which the kidney functioning declines slowly, but steadily. Chronic renal failure is a gradual process which goes on for weeks, months, or years, and the kidneys slowly stop working. The main function of kidneys is to remove waste from the body and prevent toxins from building up in the bloodstream. They also produce hormones that control other body functions.
The most common causes are diabetes (type 1 or type 2 diabetes) and high blood pressure. Damage to small blood vessels in the body is a complication arising from these two conditions. The kidney’s blood vessels also get damaged, resulting in CKD. Other common causes are a kidney infection, multiple cysts in the kidneys, urinary tract blockages, and excessive use of medications.
Chronic renal failure symptoms appear years after it starts developing. This can be caught early only by conducting regular blood tests of a suspected patient. Some signs are more obvious than others. A few signs are abnormal urination, puffy eyes, hands, and feet (called edema), high blood pressure, fatigue and shortness of breath, loss of appetite. This can also go up to seizures and mental confusion. once a patient is diagnosed with chronic renal failure, the treatment depends on the medical problem and its complications that have caused the kidney failure.
Of the various diseases prevalent in China, liver cirrhosis is one of them. Cirrhosis pertains to the scarring of the liver and poor liver function as a result of chronic liver disease. With erring weather condition, sedentary lifestyles, Beijing has been facing the wrath of liver diseases thanks to irregular patterns of eating and limited exercise.
As observed in the above literature, the improvement can be depicted by normalization of deranged liver enzymes and sonography. Anemia, ascites, esophageal varices, and any other condition related to liver damage may also potentially improve substantially with improvement in liver architecture due to the infused stem cells.
Parkinson's disease (PD) is a progressive movement disorder, which worsens over time. The disease causes malfunction and death of vital nerve cells in the brain, called neurons. This affects the neuron’s ability to produce a chemical called dopamine, a chemical that sends messages to the part of the brain, which controls movement and coordination. As the disease progresses, it further causes a decrease in the amount of dopamine supply to the brain, leaving a person unable to control movement normally. Unfortunately, even today, the cause is unknown, and no cure is available for this ailment. The treatment options in conventional medicine offer medication and surgery, which only manage its symptoms.
Stem cells are known to have a tangible application in Parkinson's Disease (PD). They are postulated to induce neurogenesis (regeneration of the affected portion of the brain matrix) and consequently bring about a significant reversal of symptoms. These cells have the potential to differentiate into dopaminergic (DA) neurons, which can efficiently re-innervate the regions of the brain and provide functional recovery. They also have the potential to protect and stimulate the regeneration of compromised DA neurons.
Symptoms of PD, including tremor, bradykinesia, rigid muscles, impaired posture and balance, speech, writing, and loss of autonomic movements shall improve considerably after therapy.
Vitiligo is a skin condition which causes loss of pigmentation, resulting in irregular white patches. People of all ages can be affected by it.
Mesenchymal stem cells have been found to have Immunomodulatory and immunosuppressive properties. Administration of mesenchymal stem cells in vitiligo will prevent further damage to melanocytes and reduce progression of the disease. In unstable vitiligo, if stabilization can be achieved other therapies like surgery can be used for further management. Mesenchymal stem cells also boost pigmentation over a period of time.
Alzheimer's Disease (AD), is a form of dementia. It is a progressive and degenerative brain disease. It affects the memory, thinking and behavior of the person affected. Although it is not a part of normal aging, the older you get, the greater the risk of developing Alzheimer's.
Stem cells are known to have a tangible application in Alzheimer's disease (AD). This can be observed in the following published literature:As observed in the above literature, transplantation of mesenchymal stem cells may reduce glial activation, oxidative stress, and apoptosis in the brain. The patient may experience improvement in memory, learning, and other impaired cognitive functions.
AIET stands for Autologous Immune Enhancement. The term "Autologous" signifies that the patient’s own immune cells i.e. Natural Killer (NK) cells are used. Not only the cells used, but the serum used to grow the cells are also taken from the patient’s own blood, meaning this approach doesn’t have any nonself component. This ensures that it is the safest mode of treatment, meaning no adverse reactions such as rejection or allergy, and no need for immune suppressors. The term "Immune Enhancement" signifies the enhancement of the immune system by directly cultivating the isolated immune cells of the patient in the lab and transfusing to yield the best results.
Insulin is a very important hormone that is produced by the pancreas and helps to keep the body’s blood sugar (glucose) levels in check. Diabetes is caused when there is an imbalance of insulin in the body. Following are the types of Diabetes:
A person suffering from Multiple Sclerosis (MS) loses the ability to walk independently or at all. Many others experience long periods of remission. In this, the insulating covers of nerve cells in the brain and spinal cord are damaged. With these parts of the nervous system lose their capacity to communicate. This leads to physical, mental, and sometimes psychiatric problems. Often permanent neurological problems occur as the disease advances.
The cause of Multiple Sclerosis, like many incurable diseases, is still unknown. Doctors call it an autoimmune disease, in which the body's immune system attacks its own tissues, killing in the process, a fatty substance that protects nerve fibers in the brain and spinal cord. Researchers are still in dark about why and how MS develops. According to them, a combination of factors ranging from genetics to childhood infections may be the cause.
The symptoms vary depending on which nerve of the body has been affected. The symptoms include:
Multiple sclerosis has no cure till now. Conventional treatment only helps a patient recover from an MS attack faster, modify the course of the disease and manage symptoms.
Cardiovascular Disorder (CVD) is the term used for disorders related to the heart or blood vessels (arteries, capillaries, and veins), or both. Stem cells are known to have a tangible application in Cardiovascular Disorders (CVD).
Erectile dysfunction is the repeated inability to get or keep an erection firm enough for sexual intercourse. ED becomes more common as you get older. But male sexual dysfunction is not a natural part of aging. Various factors can cause ED such as psychological factors, physical factors, medications, and other external conditions. Damage to nerves, arteries, smooth muscles, and fibrous tissues are often the most common causes of the disease.
In the treatment for erectile dysfunction (ED), freshly isolated cells are administered so that it can induce smooth muscle regeneration, neural regeneration, and restoration of the endothelial function. Mesenchymal Stem Cells (MSCs), given in the right environment, differentiate into diverse cell types, which are capable of replacing damaged or dysfunctional tissues of the penis. These cells express endothelial and smooth muscle phenotype, which raises the possibility that their population may be effective in either replacing or rejuvenating the dysfunctional tissues of the penis.
Muscular Dystrophy (MD) is a group of muscle disorders that generally appear before the age of 6, in which muscles of the body start deteriorating one after the other, making a patient weak with the passage of time. In muscular dystrophy, the deterioration happens rapidly and progressively and ultimately reaches the muscles of the heart and respiration, leading to death. The disorder is caused due lack of dystrophin, a type of protein, in the gene of the patient’s parent. Males are more likely to develop muscular dystrophy symptoms.
Stem cells are known to have a tangible application in the treatment for Muscular Dystrophy (MD). These cells, by property, can regenerate affected muscles by inducing myogenesis and provide a decent symptomatic relief. While the expected deterioration of patients of MD is about 20% every year, the absence of deterioration by that percentage after therapy is generally acknowledged as an improvement by most practicing doctors. Stem cell therapy can halt the progression of the disease which can prevent further complications of the disorder.
The strength, power, tone, and reflexes of muscles will improve with this therapy due to the regeneration of new muscle fibers within the afflicted muscle bundle and this, in turn, should mitigate most of the symptoms.
A spinal cord injury, most of the times, is a result of a sudden, traumatic blow to the spine. The injury displaces bone fragments, disc material, or ligaments bruise or tear into spinal cord tissue. An injury does not sever it, but mostly fractures and compresses the vertebrae, which destroys nerve cells extensions called axons that carry brains signals up and down the spinal cord. While a person recovers from some injuries, some others result into complete paralysis.
Stem cells are known to have a tangible application in Spinal Cord Injury (SCI). These cells, by the property are postulated to induce neurogenesis (regeneration of the affected portion of the brain matrix and spinal cord) and consequently bring about a significant reversal of symptoms. Improvement is reached through restoration of the lost (impaired) neuron connections and formation of the new neuronal connections; speeding up brain reactions through improvement of synaptic transmission and development of the new neuronal connections. Multiple paracrine factors and interleukins secreted by stem cells contribute to endogenous repair.
The patient can feel a symptomatic improvement in sensorimotor functions after therapy.
Autism is a developmental disorder that affects social interaction, verbal and non-verbal communication and can also lead to restricted and repetitive behavior. It affects how information is processed in the brain, and though the exact causes are not known, genetic factors seem to be important. This disorder normally appears within the first 3 years of a child and affects boys three to four times more often than girls. Most parents of autistic children suspect that something is wrong by the time the child is 18 months old and seek help by the time the child turns two.
All the symptoms of autism, including speech, mannerisms, social interactions, hyperactivity, repetitive behaviors, emotional well-being, maintenance of eye-contact and overall communication skills may improve considerably after therapy.
Cerebral Palsy, is any disorder of movement, learning, hearing, seeing and thinking. Most of these problems occur before a person is born, due to brain infections or injuries caused to it. Premature infancy can also lead to bleeding or infection.
Symptoms include abnormal movements, abnormal sensations, abnormal muscle tone, decreased intelligence, difficulty sucking or feeding in infants, hearing problems, drooling, irregular breathing, learning disabilities, speech and vision problems, etc. In conventional therapy, doctors’ tests aim at confirming all the above symptoms. Unfortunately, there is no cure even after the /confirm/iation. The goal of treatment is to help the person be as independent as possible.
All the symptoms of CP, including speech, self-esteem, emotional well-being, walking, muscle spasticity, balance, posture, movement coordination, and overall physical and communication skills may improve considerably after therapy.
Hair loss is a huge problem that men and women of all ages face today. Although hair loss is a natural process, some who lose it early in life, get a premature sense of aging. Hair loss is a far more common problem than most people would think. It can be caused by several factors including hereditary, poor nutrition, infections, hormones, pregnancy, stress, prolonged illnesses, etc. The most common cause of hair loss is androgenic alopecia, which is generally hereditary. If you are losing your hair at a rapid pace you need to take action to stop it. With more and more people looking for natural and long-lasting solutions for baldness, the demand for hair transplant has increased tremendously.
Osteoarthritis is the most common form of arthritis and is a degenerative disease that mostly affects the cartilage of joints. Cartilage is a slippery tissue that covers the bones in a joint so as to allow them to glide over each other as well as absorb shocks. When the cartilage breaks or wears away, the exposed bones then grind and rub over each other causing pain and swelling, due to which a person has trouble in moving his damaged joint. Over time, the shape of the joint may also get abnormal. The broken bits of bone or cartilage float inside the joint space, causing more pain and damage. Unlike other forms of arthritis, Osteoarthritis affects only a patient’s joints and doesn’t hit any of the internal organs. Although this occurs mostly in old people, younger people may also develop it occasionally if there is a joint injury. The exact causes are unknown, but it could happen due to factors like being overweight, old age, injury to the joint, genetic defect, stress on the joint, lack of proper joint control, etc. There is no test to diagnose Osteoarthritis as such. Doctors use medical history, examine symptoms, get X-rays and test blood or other fluids in the joint to come close to finding out whether someone has it. The treatment generally includes exercise, weight control, rest and joint care or ultimately surgery.
Stem cells are known to have a tangible application in Osteoarthritis (OA). Intra-articular infusion of mesenchymal stem cells into the knee joint, using our proprietary ABC technology can potentially regenerate hyaline and cartilage, which shall mitigate the symptoms of OA considerably. The regenerated cartilage shall potentially be able to halt or markedly slow down the progression of the disorder.
The patient can feel relief in the pain and stiffness in the knee joints due to the infusion of stem cells. Therapy shall improve mobility and joint health.
A stroke is a condition where brain cells die due to the interrupted or very low blood supply to a part of the brain. Low or no blood supply deprives brain tissues of oxygen and food. It is a medical emergency which needs to be treated with prompt action. Early action can save complications.
A stroke is caused by a blockage in an artery or a leaking blood vessel. Another reason can be when a blood clot (thrombus) forms in an artery supplying blood to the brain. This clot may be a result of fatty deposits that build up in arteries. An unhealthy lifestyle can lead to a range of reasons to create a blood clot or disruption of blood vessels, which can lead to a stroke.
Stem cells are known to have a tangible application in Stroke. They are postulated to induce neurogenesis (regeneration of the affected portion of the brain matrix) and consequently bring about a significant reversal of symptoms. The infusion of these cells improves blood and oxygen ow to the brain (improved perfusion), replaces damaged neurons and stimulates the formation of the new arteries. Improvement is reached through restoration of the lost (impaired) neuronal connections and formation of the new neuronal connections; speeding up brain reactions through improvement of synaptic transmission and development of the new neuron connections.
Rheumatoid Arthritis (RA) is an autoimmune disease that causes pain, swelling, stiffness and deformed joints. It is a form or arthritis that commonly affects the hands.
Stem cells are known to have a tangible application in Rheumatoid Arthritis (RA). They have immunosuppressive, immunomodulatory, anti-inflammatory and homing property. Anti-inflammatory cytokines secreted by mesenchymal stem cells induce the production of T regulatory cells, a type of immune cell whose function is to protect the body against immunological self-attack. Intra-articular infusion of stem cells in the joints, using our proprietary ABC technology can give rise to mesenchymal tissue like cartilage, bones, nerves etc. Stem cell therapy can also halt the progression of the disease which can prevent further complications of the disorder.
The patient can feel relief in the pain and stiffness in joints due to the infusion of stem cells.
Your body is replacing old and worn out cells all the time. In fact, it's doing it right now. However, the rate at these worn out cells get replaced, decreases as you grow older. We start looking old and also experience a decrease in energy and sex drive. While there is little you can do about aging, thanks to the advancement are medicine, it is possible to slow down this process using stem cells.
Most people are aware that stem cell therapy aims to restore the tissue and organ function for those patients who suffer from chronic diseases or serious injuries. But, did you know that this same ability makes it a very efficient anti-aging treatment by working wonders in renewing and increasing cell generation? It is because of this that the impossible task of making oneself look and feel younger has now become possible. Turn back the clock and experience the younger looking and more energetic you.
Research shows that use of stem cells and other certain treatments may help slow down the process or reverse it. Our treatment provides this unique effect of regenerating and repairing all those tissues and organs that were all damaged by stress and toxins, which people are often exposed to on a daily basis. This also results in increased stamina for daily activities and improved the functioning of the immune system.
There are several results you can expect after undergoing this treatment:Look younger: Helps reduce age spots, wrinkles and skin sagging.Feel Younger: Reduces tiredness and fatigue while also improving your energy, mental and emotional health.Reduced pains and aches: You get to enjoy more in life with reduced pains and aches in stiff joints and the effects of the degenerative disease.