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Welcome to JM’s Immunology Laboratory

JM’s Immunology Diagnostic Laboratory (IDL), performs state-of-the-art genetic testing, flow cytometry and cellular immunology studies to diagnose immunologic disorders. The IDL monitors immune function in patients with suspected or diagnosed primary immune deficiency; patients undergoing hematopoietic stem cell or solid organ transplantation; and patients treated with immune-modulating drugs.

Testing presently available includes 8-to-12-color multiparameter immunophenotyping of regulatory T cells; expression analysis of key intracellular proteins; functional testing of intracellular signalling pathways; and genetic testing for immunodeficiency disease. Development of new and innovative testing approaches to evaluate human immunity is a key focus of the IDL.

The field of diagnostic immunology has advanced significantly over the years. As technology improves, we are able to provide accurate results in shorter timeframes with less inconvenience for the patient. We have an active research program at Cincinnati Children’s, and keeping up with scientific discoveries and technology has been a core for us. As a result, we have identified and developed tests to facilitate the diagnosis of more than 80 immune deficiencies. Our laboratory is particularly suited to the diagnosis of congenital and prematurely lethal immune deficiencies.

The Immunology services at JM’s offer a wide range of testing:

  • Highly automation performed by our Immunology core section. The methodology includes enzyme-linked immunosorbent assay and chemiluminescent assay.
  • Cellular and Innate lab perform highly esoteric assays that test functional components of the cell-mediated and innate branches of the immune system.
  • Microbial Immunology lab performs assays to aid in the serologic diagnosis of bacterial, viral, mycoplasma, and parasitic infections.
  • Protein immunology lab employs a wide variety of methods to test for complement deficiencies, monoclonal and polyclonal gammopathies, and immunoglobulin deficiencies.
  • Investigating problems with the immune system. These include when the body's immune system attacks its own tissues (autoimmune diseases) and when a body's immune system is underactive (immunodeficiency disorders).
  • Determining organ, tissue, and fluid compatibility for transplantation
  • Autoimmune immunology performs assays to detect antibodies produced by the immune system as it attacks its own body. This area employs multi-analyte fluorescence detection, Ouchterlony double immunodiffusion, immunoblot, indirect fluorescent antibody methods, and ELISA.

Common immunology and serology tests

Test Uses
Immunoglobulins These are proteins in the body that have antibody activity. Excessive amounts of these proteins may be caused by a variety of conditions including infection, autoimmune disorders, cancers, and chronic diseases. A lack of these proteins may be caused by many conditions including cancers, medicines, and chronic diseases
Rheumatoid factor Used to help classify arthritis and diagnose rheumatoid arthritis. Other tests are often used as well to classify and determine types of arthritis.
HLA (human leukocyte antigens) typing Tested to determine compatibility in organ, tissue, and bone marrow transplantation. Also tested to determine paternity, and to diagnose HLA-related disorders such as certain autoimmune conditions.


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